Two Knox Central High School students were taken by their parents to the Knox County Hospital around noon Monday, where they were treated and released for exposure to what police say was an unknown substance.
According to Police Chief Winston Tye, the drugs were on business card sized paper with as many as 50 perforated pieces, which can be sold for as much as $5 to $10 per square.
The affected students were reportedly delusional, hallucinating and/or sick to their stomachs.
When school officials notified the police, they were told there were students at the school who were showing signs of drug use.
Through an investigation, Dante Brown, 18, of Barbourville, and an additional juvenile were arrested and charged with drug trafficking at the school.
Brown was lodged in the Knox County Detention Center, while the juvenile was transported to the Adair Youth Development Center.
Police confiscated a sheet of the substance, which was turned over to the KSP crime lab for analysis.
Barbourville Police Chief Winston Tye is in charge of the ongoing investigation. Chief Tye was assisted by Patrolman Matt Hammons.
The Barbourville Police Department advises parents and students to be leery of small pieces of paper with random colored images or what appears to be a wet spot on it. If it is, in fact, LSD, it can be absorbed directly into the skin.